MitoSciences said that the tests, developed in collaboration with the University of Oregon, allow clinicians to identify adverse effects from drugs used to treat HIV/AIDS, hepatitis and other infectious diseases. Many of these drugs are known to cause toxic side effects, often due to inhibition of mitochondrial function.

MitoSciences claimed that it has developed the MitoTox line of assays, which is a set of solutions for identifying adverse mitochondrial effects caused by a wide range of therapeutic compounds. The MitoTox line of assays is offered both as kits and also as a service through MitoSciences’ CRO division.

Additionally, it is also working to validate several of the MitoTox assays for use in clinical applications, such as companion diagnostics, and in this effort is collaborating with leading clinical researchers in multiple countries.

Reportedly, the problem of mitochondrial toxicity is now sufficiently well-recognised that the FDA recently released recommendations that all new antiviral drug candidates should be screened for toxicity to mitochondria. MitoSciences’ tests have been used by multiple antiviral drug developers in their FDA submissions.

Jean-Paul Audette, CEO of MitoSciences, said: “Drug-induced mitochondrial toxicity is a problem that is receiving growing recognition. A number of drugs that were removed from the market are now known to inhibit mitochondrial function, and we are working with groups at most of the world’s largest drug companies to help them include mitochondrial toxicity screening earlier in their safety assessment programs.”