Due to its excellent biocompatibility, biodegradability, and tunability, Gelatin methacryloyl (GelMA) is probably the most popular biomaterial used in 3D bioprinting, tissue engineering and 3D cell culture applications.
X-Pure® GelMA is the world’s first GMP ready gelatin methacryloyl (GelMA or GelMOD), making it suitable for preclinical and clinical applications in regenerative medicine. When using X-*Pure GelMA, you can rely on:
Synthesizing your own GelMA results in products with a high variability in methacryloyl functionalization and Molecular Weight, which in turn results in variable mechanical properties. This is due to the lack of process control associated with the synthesis and purification process found in scientific literature. The same variability is also seen in many commercial GelMA products. In contrast, X-Pure GelMA comes with high reproducibility and controllability in terms of composition and biophysiochemical properties.
Analysis of commercially available GelMA products showed a high and variable level of soluble impurities such as LPS, Methacrylic acid (MA) and DNA and even the presence of insoluble debris in all products (pellets after centrifugation of 1-ml of 8% w:w solutions). Rousselot’s process securely removes precursor and process impurities, resulting in consistent and ultra-low impurity levels.
The process used to produce X-Pure GelMA can be scaled from 10g to 100kg scale, using the same basic chemical reactions and purification methods. This assures a functional equivalence between X-Pure Research Grade and GMP grade GelMA products, meaning that you don’t have to requalify when switching to the GMP product.
Key features of X-Pure GelMA