Product

X-Pure® GelMA

February 9, 2022

Due to its excellent biocompatibility, biodegradability, and tunability, Gelatin methacryloyl (GelMA) is probably the most popular biomaterial used in 3D bioprinting, tissue engineering and 3D cell culture applications.

X-Pure® GelMA is the world’s first GMP ready[1] gelatin methacryloyl (GelMA or GelMOD), making it suitable for preclinical and clinical applications in regenerative medicine.  When using X-*Pure GelMA, you can rely on:

• A consistent product with low batch-to-batch variability

Synthesizing your own GelMA results in products with a high variability in methacryloyl functionalization and Molecular Weight, which in turn results in variable mechanical properties. This is due to the lack of process control associated with the synthesis and purification process found in scientific literature. The same variability is also seen in many commercial GelMA products. In contrast, X-Pure GelMA comes with high reproducibility and controllability in terms of composition and biophysiochemical properties.

• A gelatin with low levels of endotoxins and other impurities

Analysis of commercially available GelMA products showed a high and variable level of soluble impurities such as LPS, Methacrylic acid (MA) and DNA and even the presence of insoluble debris in all products (pellets after centrifugation of 1-ml of 8% w:w solutions). Rousselot’s process securely removes precursor and process impurities, resulting in consistent and ultra-low impurity levels.

• A gelatin made with a scalable process

The process used to produce X-Pure GelMA can be scaled from 10g to 100kg scale, using the same basic chemical reactions and purification methods. This assures a functional equivalence between X-Pure Research Grade and GMP grade GelMA products, meaning that you don’t have to requalify when switching to the GMP product.

Key features of X-Pure GelMA

• Tunable physical and chemical properties
• Crosslinking allows tunable physical environments suitable for a variety of cell types
• Functional at body temperatures
• Thermostable at 37oC
• Ultra-low endotoxin levels, suitable for sensitive applications
• Can support cell maintenance and growth
• Customized GelMA upon request.
• Soon be available in GMP grade