Product

Ocular Specialties

November 6, 2020

Toxikon is focused on evaluating the safety and toxicity of biologics, pharmaceuticals and medical devices. Our experienced study directors will provide you with the expertise in ophthalmology models and endpoints for your ocular drug and device programs.

As part of our extensive custom research and testing portfolio for ophthalmic discovery, we offer a variety of preclinical services, including the screening of neuroprotective compounds and creation of in-vivo models for glaucoma research.

Our multidisciplinary team provides expertise in the scientific and technical disciplines of ophthalmology, pharmacology, analytical and bioanalytical chemistry, and toxicology. Performed in a variety of models, Toxikon’s preclinical ocular studies include acute irritation, ocular tissue distribution, pharmacokinetic / pharmacodynamic (PK/PD), dose escalation, acute and repeat dose toxicity, required ISO and OECD/ ICH guideline testing programs, implantation, and drug screening and efficacy. Additionally, ocular protocols can be customized for targeted therapeutics, including ocular disease models.

Specialized Ocular Capabilities include:

• – Ocular Examinations
• – Corneal Sensitvity and Thickness Measurements
• – Pupillary Response Assessment
• – Retinal Function
• – Photography and Videography
• – Laser Photocoagulation
• – Fluorescein Angiography
• – Tissue Dissection
• – Microsurgery
• – Histopathology
• – Immunology
• – Confocal Microscopy
• – PK, PD, TK