The Monocyte Activation Test (MAT) can detect both endotoxin and non-endotoxin pyrogens by utilizing a reproducible cell line, coupled with an ELISA readout. In contrast to the Rabbit Pyrogen Test, this alternative method, assay produces sensitive results based on the human immune reaction.. With our Mono-Mac-6 cell-line, or cryopreserved blood-based MAT kits, we provide a robust, reliable and standardized method for pyrogen detection.