Switzerland-based Roche has introduced a new protein melting application for its PCR LightCycler 1536 instrument, allowing it to perform thermal shift assays (TSAs).

Suitable for biotech and pharmaceutical firms, contract research organizations and large academic research groups, the fully automated platform helps life science researchers to carry out TSAs in 1536-well applications quickly and consistently.

Roche life Science application support consultant Dr Rama Badugu said: "Now researchers who currently run protein thermal shift assays on Roche’s LightCycler 480 instrument, using 96- or 384-well throughput, can also run these reactions on the LightCycler 1536 instrument.

"That enables them to increase throughput while reducing the amount of protein used in the reaction, which is a key benefit of the LightCycler platform."

According to the company, the LightCycler 1536 instrument is a rapid, high-throughput, plate-based real-time PCR amplification and detection system.

Based on LightCycler 480 platform, the instrument aggregates optical unit and block cycler technology and generates 1,536 data points in a single PCR run in less than 50 minutes.

It can also produce data for high-throughput gene expression profiling and high-throughput genotyping.