LGC Standards has added human cell genotoxicity testing kits (GreenScreen HC and BlueScreen HC) from Gentronix to its portfolio of life science research and drug discovery products.
GreenScreen HC and BlueScreen HC are human cell based assays for determining the potential genotoxic effects of new drug candidates earlier in the discovery process.
Both assays use patented gene reporter systems with either Green Fluorescent Protein (GFP) or Gaussia Luciferase (G Luc) to detect up-regulation of GADD-45a, a key P53 dependant response element in the DNA stress pathway.
The assays require milligram quantities of material and give results in just 48 hours and can also be conducted in the presence of S9 to detect pro-genotoxins, LGC Standards said.
LGC Standards claims that the GADD-45a reporter system provides high sensitivity and specificity, ideally suited for the accurate detection of all classes of genotoxins with very low levels of false positive results.
Gentronix chairman and CEO John Nicholson said they have seen increase in the demand for GreenScreen HC and BlueScreen HC reagent kits and look forward to working with LGC Standards to bring these important assays to an even wider audience.