In the CytoPatch Instrument the patch clamp process takes place inside a three-dimensional quartz glass microchip with integrated microfluidic channels.
The instrument comes with ion channel assays like hERG, NaV1.5, K V1.5 and KV1.3.
The chip technology in combination with a perfusion system is suited for measuring the inhibitory effect of slowly acting compounds (permanent application of 10 minutes possible) or the very fast activating and desensitizing ligand-gated ion channels (compound application time of <10 ms).
Cytocentrics CEO Thomas Knott said it delivers a very high data quality at manual patch clamp level and enhances the productivity through automation and long walk-away times.
Cytocentrics claims one CytoPatch Instrument can perform either as a stand-alone device or as a multiple-unit system in which up to 20 individual instruments can be connected on a network.
The modular built-up minimizes delay times and even makes it possible to run different assays in parallel with different cell types.
