The National Institute of Health awards a multimillion grant to quantify microstructural changes in Alzheimer's Disease using Restriction Spectrum Imaging


The grant will allow to deliver an automated AI solution in a clinical setting. (Credit: Michal Jarmoluk from Pixabay) has received a $1.35 million, 2.5-year grant from the National Institutes of Health (NIH), National Institute on Aging to advance Alzheimer’s Disease (AD) diagnosis. The grant will allow to deliver an automated AI solution in a clinical setting to enable physicians to quickly determine a patient’s risk of developing AD and monitor disease progression and response to treatment.

“We are thrilled to receive support from the NIA to further advance this promising technology in the area of Alzheimer’s Disease diagnosis,” said Nathan White, CTO of and co-inventor of Restriction Spectrum Imaging. “The development of new therapeutics for prevention and treatment of the disease would greatly benefit from robust, objective quantitative imaging biomarkers that reflect subtle underlying pathological brain changes that occur early in the disease process.”

Alzheimer’s Disease, a progressive neurodegenerative disorder, is characterized by β-amyloid deposits and neurofibrillary tangles preceding neuronal loss and cognitive decline. While diffusion imaging has been used effectively in diseases involving specific white matter pathways, the recent advances in diffusion imaging techniques – particularly multi-compartmental models for successfully quantifying microstructural changes – now enable the effective use of diffusion imaging in Alzheimer’s Disease. The project aims to use an advanced diffusion MRI technique called Restriction Spectrum Imaging to quantify the subtle microstructural changes in Alzheimer’s patients’ brains, making it possible to detect pathological changes in the brain without an autopsy.

Cortechs Labs holds the patent on “Restriction Spectrum Imaging.” The project titled “Quantifying microstructural changes in Alzheimer’s Disease using Restriction Spectrum Imaging” is one of many projects for which received research grants.

Source: Company Press Release