Cellecta has introduced the DriverMap Adaptive Immune Receptor DNA (AIR-DNA) T-cell receptor (TCR) and B-cell receptor (BCR) kits to offer more insights into immune repertoire diversity by profiling TCR and BCR variability in genomic DNA.
According to the US-based genomic products and services provider, DriverMap AIR-DNA provides rapid, single-tube polymerase chain reaction (PCR)-based assays.
The assays are intended to analyse the genomic diversity of receptors from a range of sample types like tissue biopsies, whole blood, and formalin-fixed paraffin-embedded (FFPE).
Cellecta has designed the multiplex-PCR assays to profile the variations of the four TCR or three BCR chains contained in the genomic DNA of immune samples.
The assays use next-generation sequencing (NGS) to offer important information on each sample’s abundance and diversity of T- or B-cell clonotypes, Cellecta said.
Cellecta president and chief scientific officer Alex Chenchik said: “We are pleased to introduce the DriverMap AIR-DNA assays, which along with our AIR-RNA profiling assays provide researchers with more effective tools for immune receptor repertoire profiling.
“No other assay on the market today allows for the comprehensive, accurate and quantitative data that are obtained from the DriverMap AIR-DNA and AIR-RNA assays.”
As per Cellecta, the new AIR-DNA profiling assays complement its existing DriverMap AIR-RNA assays.
Combining profiling data from both the AIR-DNA and AIR-RNA assays can reveal important details about the clonotypes and receptors that are activated in response to certain antigens, the genomic products provider added.
This information will help to understand immune system responses to tumorigenesis, pathogens infection, and drug/vaccine treatment.
Cellecta said that the information will also serve as the foundation for developing new approaches for evaluating the efficacy of vaccines, biomarker discovery, and immune-based cancer therapies.
Additionally, the genomic products and services provider offers the DriverMap AIR-DNA or AIR-RNA profiling assays as a service. The company provides quantitative clonotype data and an analysis report from immune-cell samples sent by researchers.
