BioLife Solutions announced that it has launched two new improved packaging options for its BloodStor and CryoStor cryopreservation freeze media products.
Current aseptic processing methods predominantly rely on repeated access and dispensing from media containers, via pipetting from the open mouth of the bottle, which carries an increased risk of contamination.
Emerging best practices supported by the International Society for Cellular Therapy (ISCT) and the Foundation for the Accreditation of Cellular Therapy (FACT) include optimization steps to build and maintain sterile, closed system processing operations to reduce the risk of bioburden introduction to the biologic payload in storage and freezing containers.
BioLife’s BloodStor 55-5, a generic 55% DMSO/5% Dextran cryopreservation freeze media formulation used in cord blood banking, is now available in sterile, single-use syringes with a fill volume of 8ml, supporting manual and automatic processing of cord blood units.
CryoStor, BioLife’s proprietary cryopreservation freeze media product, widely utilized in regenerative medicine development projects and clinical trials, is now also available in single-use syringes with a 10ml fill volume.
Sterile, single-use syringes support improved aseptic processing by enabling a direct luer connection to the biologic freezing bag; supporting manual or automatic dispensing with the use of a syringe pump. Biocompatible materials include a proprietary cyclic olefin polymer syringe body, FluroTec film coated plunger, and polymethylpentene tip cap.
Supporting high volume processing operations, BioLife has also launched one-liter bulk dispensing bag options for BloodStor and CryoStor. In addition to reduced packaging, bulk bag containers include traditional spike and luer connectors and also a tail of weldable/dockable tubing, enabling sterile connections to the final freezing container outside a laminar flow hood.
Aby J. Mathew, PhD, Senior Vice President & Chief Technology Officer at BioLife Solutions, commented on the introduction of these new packaging options for BioLife products by stating, "Our active involvement with customers and industry organizations such as ISCT, AABB, and IBC Life Sciences enabled our team to respond to the need for new packaging alternatives that support improved aseptic processing of clinical cells and tissues. We strive to support the continuous evolvement of best practices in the development and commercialization of cell and tissue therapies."