Nanobody-based technology will not only have the potential to rapidly deliver an effective and safe testing and treatment solution for Covid-19, but also provide an economic, scalable, high-yield and large-scale production capability
Beroni Group announce that further to its announcement on August 4, 2020 regarding the development of a medical solution utilizing nanobody technology for COVID-19, it has just signed an agreement with GenScript Biotech Corporation (HKSE: 1548) (“Genscript”), a company listed on the Hong Kong Stock Exchange, to conduct antibody characterization and optimization through humanization and affinity maturation with the objective of increasing the antibody affinity to target the antigen by five to ten-fold.
Genscript will render the services based on 3 phases: (1) Perform pseudovirus neutralization assay with candidate antibody (2) Production and characterization of humanized antibodies and (3) Using PML (Precise Mutagenesis Library) and FASEBA (Fast Screening for Expression, Biophysical-Properties and Affinity) to carry out affinity maturation and purification of the antibodies. The process is expected to take 15-18 weeks.
Nanobody-based technology will not only have the potential to rapidly deliver an effective and safe testing and treatment solution for COVID-19, but also provide an economic, scalable, high-yield and large-scale production capability. These are key benefits for addressing the current pandemic and potential global treatment issues.
Jacky Zhang, Chairman and CEO of Beroni Group, said, “We are pleased to be able to work with Genscript, one of the world’s largest molecular biology CDMO (Contract Development and Manufacturing Organization) companies, to use their leading CDMO platform to further advance our study into the use of nanobodies for treating COVID-19 patients. Nanobody, which has more natural advantages than traditional antibody, is more suitable as a neutralizing antibody to treat coronavirus patients.
Nanobody treatment is fast emerging as an effective antibody drug in the market. We will do our utmost best to accelerate our clinical study so that we can produce a timely, safe and effective medical solution to help stop the global spread of this highly infectious disease.”
Brian Min, CEO of GenScript ProBio, said, “COVID-19 is still on the rise globally. During this period, we are pleased to collaborate with Beroni Group to use our CDMO platform to facilitate research on nanobodies for the treatment of COVID-19 patients. It is believed that with our joint efforts, this technology can appear in the market as soon as possible for the benefit of patients.”
Source: Company Press Release