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Home » products » Drug-Eluting Coatings

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Drug-Eluting Coatings

December 20, 2010

BaymedixTM CD 500 is widely tunable, allowing the target drug to be completely released in as little as a few hours, or up to several months. The tunability also means a range of substances can be released, from small molecule drugs to biopharmaceuticals. Release kinetics are first-order with little or no burst effect.

BaymedixTM CD 500

BaymedixTM CD 500 is a coatings platform for tailored drug release made using a unique blend of hydrophobic and hydrophilic polymers. Tunable release has been demonstrated with a variety of drugs, including sirolimus, paclitaxel, IL-1RA, dimethyloxalylglycine and dexamethasone.

Key features of BaymedixTM CD 500 – Drug Eluting Coatings

  • Widely programmable release kinetics
  • Accommodates diverse targets: small molecules to protein therapeutics
  • Allows multiple, simultaneous drug release
  • Strong and flexible
  • Covalent bonding to metal: excellent adhesion
  • Withstands high deformations without cracking or flaking

Application steps

  1. Chemical functionalisation of substrate
  2. Polymer grafting to substrate – primer layer
  3. Application of drug-eluting polymer blend
  4. (Optional) Application of top-coat

Characteristics

  • Covalent attachment of coating to substrate for strong adhesion
  • High resistance to delamination in situ
  • Optional top-coat to modify release profile
  • Succesfully implemented on:stainless steel, cobalt-chromium, nitinol

 

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