MDROs included in the study consist of Acinetobacter baumannii, community-associated methicillin-resistant Staphylococcus aureus, extended-spectrum beta-lactamase-producing bacteria and Clostridium difficile.

To investigate the antimicrobial efficacy of Aquacel Ag dressing, four models were selected to simulate stringent clinical conditions, while non-silver AQUACEL dressing was used as a control.

The simulated wound fluid model was used to measure sustained antimicrobial activity over time, while the simulated colonized shallow wound model was used to investigate the effect of dressing conformability on activity of AQUACEL Ag dressing.

Other models used in the study include simulated colonized wound surface model to investigate the antimicrobial activity of the silver dressing against a variety of MDROs seeded into agar directly beneath the dressing and the biofilm model to assess the antimicrobial activity of the AQUACEL Ag dressing when each of the MDROs was expressing a biofilm phenotype.

The study results concluded that throughout all test methods, AQUACEL Ag dressing was shown to have consistent antimicrobial activity against a variety of MDROs.