ClearPoint Neuro, a global therapy-enabling platform company providing navigation and delivery to the brain, today announced an exclusive worldwide agreement with NE Scientific, LLC, a leader in biophysics simulation, to develop a GPU-accelerated software solution for modeling of drug infusions delivered with the ClearPoint SmartFlow cannula. Under the terms of the agreement, this first of many software collaborations will enable simulation of patient-specific infusion in real time to predict the distribution of therapeutic agents in 4D before the actual procedure.
Coupled with Maestro, this new software will allow optimization of infusion parameters including target points, flow rate, infusion coverage and leakage outside of target-specific boundaries. The simulation software will require standard structural and diffusion pre-operative MRI scans. Infusions can be planned either in the pre-operative MRI space and registered to intra-operative MRI case data, or in the OR space using an intra-operative CT.
“The accuracy of the ClearPoint system allows for precise dosing and targeted delivery of therapeutic agents across the blood brain barrier. Real time simulation of patient-specific infusion would be of tremendous help to neurosurgeons performing these procedures. It presents a unique opportunity for optimization and monitoring of infusion parameters, including cannula tip location, flow rate, and percentage coverage,” commented Lyubomir Zagorchev, Vice President, Clinical Science and Applications at ClearPoint Neuro. “Accurate patient-specific quantification and visualization of infusion coverage has the potential to change the current practice of setting up fixed clinical protocols for pharma trials. The dose of delivered therapeutic can be visualized and quantified during a procedure based on patient-specific data. That will reduce variability that may lead to sub-optimal delivery, and even failed clinical trials.”
Source: Company Press Release
