For the first time in the US, doctors at Bascom Palmer Eye Institute at the University of Miami Miller School of Medicine have used a rare procedure to help a blind woman to regain her sight. Doctors in this procedure implanted blind woman eyetooth in her eye, as a base to hold a prosthetic lens. The procedure, called modified osteo-odonto-keratoprosthesis (MOOKP).
On Labor Day weekend, after the last in a series of surgeries by corneal specialist Victor L. Perez, M.D., associate professor of ophthalmology at Bascom Palmer Eye Institute, bandages were removed from Thornton’s eyes and she was able to recognize faces only hours after her surgery. Two weeks following her surgery, she is already reading newsprint with a visual acuity of 20/70 and it is expected to improve further as her surgical scars heal.
Developed in Italy, MOOKP has proven effective as a solution to end-stage corneal disease where severe corneal scarring blocks vision and corneal transplants are no longer an option but the eye’s internal structures and optic nerve remain healthy. Patients may have suffered trauma to their cornea, the outside surface of the eye where a contact lens would sit, from chemical injuries, thermal burns, and inflammatory or autoimmune disorders, such as Stevens-Johnson syndrome.
“For certain patients whose bodies reject a transplanted or artificial cornea, this procedure ‘of last resort’ implants the patient’s tooth in the eye to anchor a prosthetic lens and restore vision,” explained Dr. Perez. “In Sharron’s case, we implanted her canine tooth, her eyetooth.”
Dr. Perez’s interdisciplinary team included Yoh Sawatari, D.D.S., assistant professor of clinical surgery at the Division of Oral and Maxillofacial Surgery and Dentistry at the University of Miami Miller School of Medicine, who extracted the patient’s canine or “eyetooth” and surrounding bone. In MOOKP, the tooth and surrounding bone are shaved and sculpted, and a hole is drilled for the insertion of an optical cylinder lens. Next, to bond the tooth and lens as a bio-integrated unit, they are implanted under the patient’s skin in the cheek or shoulder. Meanwhile, the ophthalmologist prepares the surface of the eye for implantation of the prosthesis by removing scar tissue surrounding the damaged cornea.
About one month later, mucous material is collected from the inside of the patient’s cheek and used to cover and rehabilitate the surface of the damaged eye. In the final phase, usually two months later, the prosthesis is removed from the cheek or shoulder and implanted in the eye. The prosthesis is carefully aligned with the center of the eye, and a hole is made in the mucosa for the prosthetic lens, which protrudes slightly from the eye and enables light to re-enter the eye allowing the patient to see once again.
For Thornton, the surgery marked the successful conclusion of a nine-year medical odyssey that started at the onset of Stevens-Johnson syndrome.